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Anti-microbial Nanohybrids Based on Naturally Derived Citric Acid Intercalated Layered Double Hydroxides

Authors:

Shashikala Kuruppu ,

University of Sri Jayewardenepura, Gangodawila, Nugegoda, LK
About Shashikala
Department of Chemistry, Faculty of Applied Sciences
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Upendra Rathnayake,

Cool Springs Life Science Center, 393 Nichol Mill Lane, Suite 100, Franklin, TN 37067, US
About Upendra
Warren Center for Neuroscience Drug Discovery
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Madhavi de Silva,

University of Sri Jayewardenepura, Gangodawila, Nugegoda, LK
About Madhavi

Department of Chemistry, Faculty of Applied Sciences

 

Center for Advanced Materials Research, Faculty of Applied Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda

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Thilini Rupasinghe,

University of Kelaniya, LK
About Thilini
Department of Chemistry
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Chanaka Sandaruwan

Sri Lanka Institute of Nanotechnology, Pitipana, Homagama, LK
About Chanaka
Center for Excellence in Nanoscience and Technology
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Abstract

Currently, there is an increased demand for advanced food packages, which can significantly increase the shelf life of food items. In the current context, it is envisaged that nanotechnology has the potential to address stability, toxicity, shelf-life, and low-cost issues of antimicrobials associated with the packaging industry. Antimicrobial nanocomposite systems are believed to be more efficient than their microscale counterparts due to the high surface area to volume ratio and quantum mechanical involvement in deciding their properties. As a result of high surface area, they are able to attach more copies of microbial molecules and cells, thus reducing the quantity of material required while significantly improving their activity. This study focuses on the development of slow-release antimicrobial material based on natural citrate (α-hydroxycitrate) intercalated layered double hydroxide (LDH) nanohybrid. Natural citrate ions available in Citrus aurantifolia (lime) were extracted by a simple chemical method and intercalated into Mg-Al-Layered Double Hydroxide following a one-step co-precipitation method. Successful intercalation of the citrate ion was confirmed by powder X-ray diffraction (PXRD) and Fourier transform infrared (FTIR) spectroscopic analysis. Release kinetics of resulted nanohybrid was studied and compared using different release kinetic models. Antimicrobial properties of this novel nanohybrid were confirmed against two common food pathogens, Colletotrichum gloeosporioides and Saccharomyces cerevisiae, and the results were compared against sodium benzoate, which is the commonly used commercial antimicrobial agent in the food industry. Successful intercalation of natural citrate ions into LDH and its activity against the tested microbes show the potential of using it as a slow-release nanohybrid material in many food-related applications.
How to Cite: Kuruppu, S., Rathnayake, U., de Silva, M., Rupasinghe, T. and Sandaruwan, C., 2022. Anti-microbial Nanohybrids Based on Naturally Derived Citric Acid Intercalated Layered Double Hydroxides. Vidyodaya Journal of Science, 25(1), pp.122–136.
Published on 18 Aug 2022.
Peer Reviewed

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